Muhiddin HS, Kamaruddin MI, Ichsan AM, et al. - In the present study, the researchers sought to examine vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) concentrations in vitreous and serum samples, analyze the ratio, and compare it among proliferative subgroups of diabetic retinopathy (PDR). They involved 17 eyes of patients with PDR, identified as the PDR group which was divided into three subgroups (vitreous hemorrhage [VH], VH with fibrotic tissues, and tractional retinal detachment), and five control eyes (nucleus and intraocular lens drop). In PDR pathology, high concentrations of VEGF and PDGF in vitreous samples of PDR eyes indicate its local related activity. PDGF involvement in PDR pathogenesis is a possibility. The concentration ratios of VEGF/PDGF likely play a significant role in PDR fibrotic tissue formation.