Kubiak JM, et al. - Authors evaluated the impacts of vitamin D supplementation on cardiovascular disease (CVD) risk factors in vitamin D insufficient subjects. They conducted a 4 months interventional study with high dose vitamin D (100,000 IU loading dose, followed by 20,000 IU/week) or placebo with measurements of blood pressure, lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B), and glucose metabolism parameters (blood glucose, HbA1c, sRAGE, insulin, C-peptide, and HOMA-IR). Findings suggested that in subjects with baseline vitamin D insufficiency, CVD risk factors profile was not improved with supplementation with vitamin D.