Fan X, Wang J, Song M, et al. - A prospective cohort study was performed to evaluate the correlation between vitamin D status and risk of all-cause and cause-specific mortality and calculate optimal serum 25-hydroxyvitamin D [25(OH)D] concentrations. Researchers included a total of 365,530 participants who had serum 25(OH)D measurements and no history of cardiovascular disease (CVD), cancer, or diabetes at baseline (2006-2010). The study found that higher 25(OH)D concentrations are nonlinearly correlated with a lower risk of all-cause, CVD, and cancer mortality. The results considered that thresholds of 45 to 60 nmol/L might represent an intervention target to reduce the overall risk of premature death, which requires further validation in large clinical trials.