Kluwe L, et al. - Researchers explored the role of the vitamin D receptor in preventing development and progression of neurofibromas. They analyzed 141 adult neurofibromatosis type 1 (NF1) patients, with available serum vitamin 25(OH)D data in 101. In PaxGene tubes containing a reagent to stabilize RNA immediately, they obtained blood samples from 87 patients. Using RT-PCR, they measured mRNA of the vitamin D receptor (VDR) gene (coding for the vitamin D receptor). They statistically assessed correlation of laboratory data with NF1-related tumors. A significant inverse correlation of the number of dermal neurofibromas with VDR mRNA level and with serum 25(OH)D concentration was evident in NF1 patients. Findings were suggestive of a possible role of both vitamin D and its receptor in suppressing the development of neurofibromas. Neurofibromas and possibly also other tumors could be controlled by sustaining 25(OH)D at an adequate level. This holds significance particularly for subjects with lower expression of VDR.