Ng KT, et al. - Researchers sought for the viral factors that increase the severity of rhinovirus (RV) infection, the transmission pattern, and seasonality of RV infections via performing an observational study among 3935 patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014. Outcomes highlight the role of viral load (VL) in increasing disease severity. In comparison with RV-A and RV-B, RV-C–infected subjects produced higher VL. The relative humidity was noted to be the strongest environmental predictor of RV seasonality in the tropical climate.