Soto-Subiabre M, Mayoral V, Fiter J, et al. - The aims of this study were to describe the prevalence of fracture risk factors in patients with vertebral fractures (VF) and to analyze their association with VF clinical presentation and severity. The study design was observational and cross-sectional. Patients were recruited between 2015 and 2018. Fracture risk factors were recorded, including bone mineral density, fracture risk assessment score, pain characteristics, analgesia required, and radiological features such as number, location(s), and grade of VF, affected segment, kyphosis angle, and spine deformity index. A series of 422 patients were included (mean age, 75 ± 9 years; 74% women). The study found previously unpublished associations between clinical and radiological characteristics of fragility VF and several fracture risk factors. The outcomes could lead to a better understanding of the complex relationships between these risk factors and clinical presentation, and should be recognized when evaluating individuals with VF.