Ventricular tachyarrhythmia detection by implantable loop recording in patients with heart failure and preserved ejection fraction: The VIP‐HF study
European Journal of Heart Failure Jul 23, 2020
van Veldhuisen DJ, van Woerden G, Gorter TM, et al. - This investigator‐initiated, prospective, multicentre, observational study, the VIP‐HF study, is done to determine sustained ventricular tachyarrhythmias (VT) incidence in heart failure (HF) with mid‐range or preserved left ventricular ejection fraction (HFmrEF/HFpEF), as well as to ascertain the incidence of non‐sustained VTs, bradyarrhythmias, HF hospitalizations and death. Patients with HF and LVEF > 40% participated in this study. Patients underwent extensive phenotyping, following which an implantable loop recorder was implanted. Overall 113 of the planned 250 patients were enrolled, with mean age of 73±8 years. Non‐sustained VTs and atrial fibrillation on Holter were evident in 18% and 38%, respectively. A median follow‐up of 657 days was performed, during which, the primary endpoint of sustained VT was noted in one patient. The incidence of the primary endpoint was estimated to be 0.6 per 100 person years. The incidence of the secondary endpoint of non‐sustained VT was estimated to be 11.5 per 100 person years. Overall, findings revealed a low incidence of sustained VT in HFmrEF/HFpEF, despite the lower than expected number of included patients. In addition, clinically relevant bradyarrhyhmias were more frequently noted than anticipated.
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