Ceriello A, Lucisano G, Prattichizzo F, et al. - Using data of 100,576 patients from the Swedish National Diabetes Register, the development of cardiovascular complications in type 2 diabetes is predicted by high body weight variability. Such findings imply that any strategy for reducing body weight in these individuals should aim for long-term maintenance while avoiding oscillations.

• After adjusting for known cardiovascular risk factors, the risk of the primary composite outcome increased significantly as body weight variability increased.

• Moreover, elevated body weight variability was linked to nearly all of the other cardiovascular complications studied (non-fatal myocardial infarction, non-fatal stroke, all-cause mortality, peripheral arterial disease, peripheral vascular angioplasty, hospitalization for heart failure, foot ulcer, and all-cause mortality).