Briones M, et al. - Varenicline (1mg BID) was examined for its efficacy determine in reducing methamphetamine use compared to placebo among treatment-seeking methamphetamine (MA)-dependent volunteers. Randomization of treatment-seeking MA-dependent volunteers to varenicline 1mg twice daily (n=27) or placebo (n=25) and cognitive behavioral therapy for 9weeks was performed. Researchers did not identify 1mg varenicline BID as an effective treatment for MA dependence among these volunteers.