Tamariz L, et al. - The utility of single nucleotide polymorphisms (SNPs) for predicting sudden cardiac death (SCD) was assessed via analyzing eligible case-control or cohort studies that reported links between SNPs and SCD. These studies were identified from Medline database (2000 to 2017) by using search terms- “polymorphisms” and “sudden death.” Overall of 723 identified studies, 24 were analyzed that fulfilled the eligibility criteria for inclusion. A total of 78,165 participants (median age was 62.5 years), of whom 35% were female, were studied. Fifty-three SNPs were assessed, SCN5A, RyR2, CASQ2, NOSA1P and AGTR being the most common genetic loci. rs6684209 of CASQ2 (OR 19), rs3814843 of CALM1 (OR 5.5), and rs35594137 of GJA5 (OR 3.6) were the SNPs with the 3 strongest statistically significant ORs >1. Overall, findings revealed an association of many SNPs with SCD. SNPs of genes associated with intracellular calcium handling demonstrated the most robust links. Primarily, by employing a candidate gene strategy in white patients with European descent, these results were produced.