Tamariz L, et al. - Researchers analyzed 24 eligible studies identified from the Medline database between 2000 and 2017 to see if there was any evidence that single nucleotide polymorphisms (SNPs) could predict sudden cardiac death (SCD). The selected studies were case-control or cohort studies and included 78,165 participants overall, with a median age of 62.5 years with 35% being female. A total of 53 SNPs were assessed in the studies, SCN5A, RyR2, CASQ2, NOSA1P, and AGTR being the most common genetic loci. Findings revealed the association of many SNPs with SCD. The SNPs of genes related to intracellular calcium handling demonstrated the strongest associations with SCD. SNPs rs6684209 of CASQ2, rs3814843 of CALM1, and rs35594137 of GJA5 had the three strongest statistically significant ORs >1. A candidate gene strategy was used in white patients with European descent to generate these results.