Chen W, Berke A, Chung W, et al. - In this retrospective analysis involving patients (n = 63; mean age: 82 ± 8 years) treated with the MitraClip for significant mitral regurgitation (MR), researchers assessed factors predictive of adverse clinical outcomes, focusing on acute alterations in hemodynamics and cardiac function. Prior to and immediately following MitraClip repair, they performed cardiac catheterization. In both ventricles, they evaluated volumetric and functional alterations. Participants were observed for a mean of 380 days. Early after MitraClip therapy, they observed a decline in left ventricular end-diastolic volume and improvement in hemodynamics. An increased risk of mortality and heart failure was observed in correlation with advanced age (≥ 85 years) and residual MR > 1+.