Unseen scars: Cocaine patients with prior trauma evidence heightened resting state functional connectivity (RSFC) between the amygdala and limbic-striatal regions
Drug and Alcohol Dependence Oct 01, 2017
Gawrysiak MJ, et al. - Amygdala functional connectivity (FC) was examined in the resting state (RS), testing for differences between cocaine patients with and without prior trauma. The authors proposed that compared to cocaine patients without prior trauma, cocaine patients with prior trauma had heightened communication within nodes of the motivational network even at rest. As per their knowledge, this was the first fMRI study to investigate amygdala RSFC among those with cocaine use disorder (CUD) and trauma history. For the Trauma group, heightened RSFC intralimbic connectivity could reflect a relapse-relevant brain vulnerability and a novel treatment targeted for this clinically-challenging population.
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