Novikov D, Feng JE, Anoushiravani AA, et al. - A multicenter retrospective review of all patients (n = 289) diagnosed with hepatitis C virus (HCV) who underwent primary total joint arthroplasty (TJA, acknowledged as one of the most successful and reproducible elective surgical procedures conducted in the United States and is projected to rise exponentially) between January 2005 and April 2018 was performed by the researchers in order to evaluate whether changes in HCV viral load (VL) affected perioperative outcomes following TJA. Patients were randomized into 2 cohorts, ie, an undetectable VL (U-VL) and detectable VL (D-VL). Prolonged operative spans, higher intraoperative blood loss, longer inpatient hospital stays, more postoperative infections, and an increased risk for revision TJA was observed in patients in the D-VL cohort. The U-VL cohort trended toward better survivorship as exhibited by Kaplan-Meier. No variation in outcomes was praised on the subanalysis of low and high VL. Hence, TJA recipients with a detectable HCV VL had more prolonged operative times, experienced more intraoperative blood loss, had longer hospital length of stay, and were more prone to encounter infection and needed revision TJA. The blood loss, hospital length of stay, and revision rate conclusions should be explained with caution since there were confounding factors. Furthermore, HCV VL was a modifiable risk factor that could decrease the risk of infection and revision surgery. Moreover, serum HCV VL was not associated with outcomes.