Kalbacher D, Tigges E, Boekstegers P, et al. - Researchers investigated how intra-hospital, short and long-term results among patients managed by MitraClip therapy were influenced by underweight, overweight and obesity. Prospective enrollment of 799 patients into the multicenter German Transcatheter Mitral Valve Interventions registry was performed from August 2010 until July 2013. These patients aged 75.3 ± 8.6 years, 60.7% were male [median logistic EuroSCORE 20% [12; 31], functional mitral regurgitation: 69.3%]. Based on BMI, 4 groups were defined: BMI <20 kg/m² (underweight), BMI 20.0 to < 25.0 kg/m² (normal weight, reference group), BMI 25.0 to < 30.0 kg/m² (overweight) and BMI ≥ 30 kg/m² (obese). Increased rates of procedural failure, bleeding and low cardiac output as well as increased short- and long-term mortality rates were observed in underweight patients, vs other weight groups, undergoing MitraClip implantation, and thus, these are recommended to be carefully discussed in the heart-team.