Fudim M, Brooksbank J, Giczewska A, et al. - Given that ultrafiltration is not often used due to higher incidence of worsening renal function without improved decongestion, researchers assessed differential results of high compared with low fluid removal and preserved vs reduced ejection fraction (EF) in CARRESS‐HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure). To determine links between fluid removal < 24 hours and composite of mortality, hospitalization, or unscheduled outpatient/emergency department visit during study follow‐up, Cox‐proportional hazards models were employed. Findings revealed that higher initial fluid removal with ultrafiltration was not related to worsening renal function in patients suffering from acute heart failure. In patients with EF > 40%, worsening renal function in correlation with ultrafiltration was observed regardless of fluid removal rate and higher initial fluid removal was shown to be related to higher rates of adverse clinical results, demonstrating variable responses to decongestive therapy.