Raio L, et al. - In normal pregnancies and pregnancies complicated by preeclampsia, researchers used a novel ultra-high sensitive assay method (uhsCRP) and assessed the longitudinal pattern of inflammatory markers, such as interleukin-6 (IL-6) and C-reactive protein (CRP). They also studied their link to angiogenic factors such as placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and vascular endothelial growth factor (VEGF). They excluded from the study the women with premature rupture of membranes (PROM) or infection such as chorioamnionitis. With the advancement of the gestation, serum levels of uhsCRP (and IL-6) were increased, this implies a shift towards an inflammatory state during normal pregnancy. In preeclampsia, uhsCRP and sFlt-1 levels were excessively elevated and were suggested to be possibly involved in its pathogenesis. Findings suggested the possible utility of uhsCRP as an early marker for preeclampsia.