Mordi IR, Lumbers RT, Palmer CNA, et al. - This study was undertaken to aaply mendelian randomization (MR) techniques to calculate the causal relationships between genetic liability to type 2 diabetes (T2D), glycemic traits, and risk of heart failure (HF). Researchers obtained summary-level data from genome-wide association studies of T2D, insulin resistance (IR), glycated hemoglobin, fasting insulin and glucose, and HF. The inverse-variance weighted method was used to conduct MR. The results imply a possible causal role of T2D and IR in HF etiology, although the presence of both bidirectional effects and directional pleiotropy indicates potential sources of bias that must be considered.