Ulrich NH, Gravestock I, Winklhofer S, et al. - This study was conducted to evaluate clinical outcomes in patients with symptomatic lumbar spinal stenosis (LSS) with and without spinal epidural lipomatosis (SEL) who had undergone decompression surgery alone at the 12- and 24-month follow-up. A total of 183 patients were included, of which 14 had mainly SEL on at least one level operated in addition to possible degenerative changes on other levels and 169 degenerative LSS only. Pain (Spinal Stenosis Measure (SSM) symptoms), disability (SSM function), and quality of life [EQ-5D-3L summary index (SI)] at 24-month follow-up, and minimal clinically important difference in SSM symptoms, SSM function, and EQ-5D-3L SI were the maine outcomes. This research indicated that at 2 years, decompression alone surgery was correlated with significant improvement in disability in both groups, but not in pain and quality of life in patients with SEL.