Richter J, et al. - Researchers tested the assumption that diet-induced thermogenesis (DIT) differs depending on the time of day and ascertained if this physiological regulation was preserved after low-calorie vs high-calorie intake. Sixteen normal-weight men twice under blinded conditions underwent a 3-day in-laboratory, randomized, crossover study. DIT is clearly higher in the morning than in the evening, regardless of the amount of calorie consumed; that is, during hypocaloric nutrition, this physiological rhythmicity is maintained. Therefore, extensive breakfast should be preferred over large dinner meals to avoid obesity and high blood glucose peaks even under hypocaloric dietary conditions.