Kim JW, et al. - Researchers conducted this retrospective analysis to determine the importance of large tumour size as a criteria for classifying advanced intraocular retinoblastoma, examining rates of globe survival and high-risk (HE) histopathologic characteristics. Using the Los Angeles (LA) Classification System (no tumour size criteria for Group E), 212 eyes diagnosed with Group D (111 eyes) or Group E (101 eyes) retinoblastoma in at least one eye from January 1, 2006, to December 31, 2016, were included. After that, the 111 Group D tumours were reclassified to Group E utilizing 10, 12, 14, 16, 18 mm tumour size criteria, as determined by ultrasound or magnetic resonance imaging dimensions. According to results, 66.7% of Group D and 10.5% of Group E eyes undergoing globe preservation therapy avoided enucleation or radiotherapy for eyes in the original LA classification. The data presented in this work showed a large tumour size criteria for Group E retinoblastoma have no clinical basis, given that the LA classification system gave the greatest separation in globe salvage rates between Group D and E eyes. Between Group D and E eyes, the LA classification system was also able to display a statistically significant variation in the rates of HE histopathologic characteristics. The authors suggest that centres use one uniform system for classifying advanced intraocular retinoblastoma to avoid mistakes in the literature.