Cioffi CE, et al. - Researchers sought to describe patterns of truncal vs peripheral fat deposition measured by truncal-to-leg fat ratio (TLR) in adolescents. In addition, they examined whether TLR is associated with cardiometabolic (CMD) risk factors. From 3810 adolescents (12-19 years old) in the National Health and Examination Survey (NHANES) 2003-2006, they obtained data indicating highest mean TLR among adolescents who were Mexican American, who have lower income, and with obesity. In linear regression, they observed a positive correlation of increasing TLR with homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides, total cholesterol, systolic blood pressure (BP), c-reactive protein, and alanine aminotransferase (ALT), and a negative correlation with high-density lipoprotein (HDL) cholesterol in both sexes. Furthermore, there appeared an association of TLR with diastolic BP in boys and with low-density lipoprotein cholesterol in girls. Among White and/or Mexican American, TLR showed a positive correlation with high triglycerides, total cholesterol, and ALT, but not among Black adolescents. The associations with HOMA-IR and HDL were significant for all race/ethnicities.