Verheul MK, et al. - Authors gauged the value of combined antibody testing (anti–citrullinated protein autoantibodies (ACPAs), rheumatoid factor (RF), and anti–carbamylated protein (anti-CarP)) in relation to prediction and diagnosis of (early) rheumatoid arthritis (RA). Since very early identification of RA and possible screening for individuals at maximum risk of RA in populations with a low pretest probability is being achieved by the rheumatology field, an interesting information that might help identify individuals at risk of developing RA was provided by an autoantibody profile of triple positivity for ACPAs, RF, and anti-CarP. Compared to the control groups, the individual antibodies were highly prevalent in patients with RA, but were also present in non-RA controls.