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Trichomonas vaginalis virus (TVV) among women with trichomoniasis and associations with demographics, clinical outcomes, and metronidazole resistance

Clinical Infectious Diseases Mar 08, 2019

Graves KJ, et al. - Researchers examined the prevalence of Trichomonas vaginalis virus (TVV) in U.S. Trichomonas vaginalis isolates. Further, they assessed the associations of TVV with patient demographics, clinical outcomes, and metronidazole resistance. From the enrollment visit of 355 women participating in a T. vaginalis treatment trial in Birmingham, AL, archived T. vaginalis isolates were thawed and grown in culture. They identified this study as one of the largest U.S. studies of T. vaginalis isolates tested for TVV. Findings revealed TVV prevalence of 40%. However, TVV+ isolates were not identified to be associated with clinical symptoms, repeat infections, or metronidazole resistance. These findings thus suggest a possibility that TVV is a commensal to T. vaginalis.
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