dos Santos MM, et al. - Researchers conducted an ecological study using secondary data from the Brazilian notification system in order to analyze the trend and regional distribution of syphilis in Brazil between 2007 and 2017. To tackle the prevalence of syphilis, a comprehensive project, called the “No Syphilis Project,” was implemented by the Ministry of Health in 100 selected Brazilian municipalities, which presented the worse outcomes related to syphilis and represented 57.7% of syphilis cases and about one third of the Brazilian population. Comparison of these priority municipalities was done with other 189 non-priority municipalities with more than 100 thousand inhabitants among the Brazilian regions (North, Northeast, Southeast, South and Center-West). All regions, particularly the South, exhibited a significant growth trend for the main three forms of syphilis (in pregnancy, congenital and acquired). High growth trends in syphilis prevalence between 2007 and 2017 indicates that in Brazil, syphilis reduction or even elimination is still difficult.