Harding JL, et al. - Since vascular complications of diabetes have decreased significantly over the past 20 years, however, the effect of modern medical therapies on infectious diseases in people with diabetes remains unknown, researchers used the 2000–2015 National Inpatient Sample and the National Health Interview Surveys to estimate rates of infections requiring hospitalizations in adults (≥ 18 years) with vs without diabetes. Using Joinpoint regression with the annual percentage change (Δ%/year) reported, trends were assessed. Overall, hospitalization rates rose from 63.1 to 68.7 per 1,000 persons in adults with diabetes and from 15.5 to 16.3 in diabetes-free adults between 2000 and 2015. Nevertheless, rates in adults without diabetes decreased by 7.9% from 2008, whereas no substantial decrease was reported in adults with diabetes. In the later period, the lack of decline throughout adults with diabetes was driven by significant increases in rates of foot infections and cellulitis, as well as a lack of decline in young adults with diabetes for pneumonia and postoperative wound infections. The findings highlight the need for greater infectious risk mitigation in adults with diabetes, particularly young adults with diabetes.