Trends in microbial profile of burn patients following an event of dust explosion at a tertiary medical center
BMC Infectious Diseases Mar 13, 2020
Chen YY, et al. - Given that in burn patients, the main cause of increased morbidity and mortality is a microbial infection, particularly caused by multiple drug-resistant organisms (MDRO). Researchers here investigated major microbial trends in burn patients. They conducted a retrospective study of burn patients admitted at burn wards and intensive care units following an event of dust explosion. Collection of a total of 1,132 specimens was performed from 37 hospitalized burn patients with mean TBSA of 46.1%. Staphylococcus spp. was the most commonly isolated species (22.4%). They identified the highest rate of antibiotic resistance in carbapenem–resistant A. baumannii (14.6%), followed by methicillin-resistant S. aureus (11.3%). Findings suggest that with the increase in TBSA and duration of time after burns, an increase in the proportion of overall microbial isolates occur. MDRO is most significantly affected by the extent of TBSA. For each additional 10% TBSA, an increase in the isolation of MDRO was observed by 2.58–17.57 times; for each additional 10% of the third-degree burn severity, a significant decrease in the risk of MDRO was evident, it decreased by 47% by Cox model.
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