Lyon TD, Shah ND, Tollefson MK, et al. - OptumLabs Data Warehouse, a national administrative claims database was used to recognized individuals who underwent radical cystectomy (RC) for bladder cancer from 2012-2017 in order to assess temporal trends in prescriptions for extended-duration pharmacologic prophylaxis (EDPP) intended to prevent venous thromboembolism (VTE) after RC. A total of 2,054 persons were recognized, including 386 who received an EDPP prescription. On multivariable logistic regression, age < 65, receipt of neoadjuvant chemotherapy, more recent procedure year, treatment in a public as compared to a for-profit hospital, and treatment at a hospital with residency training or a surgical robot were significantly related to elevated odds of receiving EDPP. Thus, EDPP following RC has risen over time, although it is still given to very less individuals. These data could be beneficial for directing quality improvement efforts provided recent literature sustaining the use of EDPP.