Fariselli C, et al. - Authors evaluated the ocular surface parameters, inflammatory marker level in tears, and mucin expression in conjunctival epithelium before and after treatment with trehalose/hyaluronate tear substitute in dry eye (DE) patients. After 2 months’ treatment with trehalose/hyaluronate tear substitute in DE patients, a decrease in ocular discomfort symptoms, surface damage, and tear cytokine levels was seen, along with a significant goblet cells (GCs) density recovery. They noted a probable association of these results with the synergic action of both trehalose and hyaluronic acid in targeting different entries of the DE vicious loop.