Yu X, et al. - For large de novo coronary lesions with diameters greater than 2.8 mm, researchers assessed the effectiveness of paclitaxel-coated balloons (SeQuent Please). A retrospective study was conducted with 527 consecutive patients with 595 de novo lesions (222 lesions) comprising the large vessel disease (LVD) group (with a reference diameter [RD] ≥ 2.8 mm) and another 373 lesions comprising the small vessel disease (SVD) group (with a RD < 2.8 mm) who received drug-coated balloon (DCB) angioplasty at the Beijing Hospital, Beijing, China. Outcomes suggest that for de novo coronary lesions with diameters greater than 2.8 mm and for small vessel lesions, DCB was equally safe and effective. This indicates the feasibility of DCB-only strategy in large de novo lesions intervention.