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Treatment of idiopathic oligozoospermia with combined human chorionic gonadotropin/human menopausal gonadotrophin: A randomized, double-blinded, placebo-controlled clinical study

Andrologia Mar 25, 2019

Zhao N, et al. - Researchers evaluated the data to estimate the advantageous effects of human chorionic gonadotropin/human menopausal gonadotrophin (hCG/hMG) therapy on idiopathic oligozoospermia in Chinese infertility population. They observed significant improvement in sperm concentration, the rate of forward motile spermatozoa, total motile sperm count, the percentage of sperm with normal morphology and the rate of spontaneous pregnancy in medium- and higher-level inhibin B group, respectively, with the administration of hCG/hMG for 3 months. At the end of treatment, a decline in medium- and higher-level inhibin B group, sperm DNA fragmentation index and spermatid concentration was noticed. No significant variations in lower-level inhibin B group before and after treatment in term of seminal parameters, DNA fragmentation, and spermatid concentration was recorded with an overall beneficial ability of hCG/hMG therapy.
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