Matthys A, Cassagne M, Galiacy SD, et al. - In this prospective, non-comparative, pilot cohort study, researchers tested the safety and effectiveness of transepithelial corneal cross-linking (CXL) with supplemental oxygen. This investigation was carried out at the National Reference Center for Keratoconus (Toulouse, France) on patients with progressive keratoconus. Transepithelial, pulsed, accelerated CXL was conducted in an oxygen-rich atmosphere. Participants in the study were 34 patients (34 eyes). Corneal haze was the most frequent adverse event. Transepithelial CXL conducted in an oxygen-rich atmosphere leads to improved Kmax and CDVA with good safety. Such positive results indicate that this procedure may be safe and capable of stopping keratoconus progression.