Kresoja KP, Lauten A, Orban M, et al. - Researchers investigated the effect of left‐sided heart failure (HF) types on results of transcatheter tricuspid valve edge‐to‐edge repair (TTVR), in this retrospective analysis. This study involved 71 HFpEF (heart failure with preserved [≥ 50%] ejection fraction) and 40 HFrEF (heart failure with reduced ejection fraction [< 50%]) patients with isolated tricuspid regurgitation (TR) managed by TTVR. A composite outcome of all‐cause death and HF hospitalization at 12 months was assessed as the primary outcome. There was no difference in procedural success between HFpEF or HFrEF patients. A more frequent occurrence of primary endpoint was reported in patients with HFrEF vs HFpEF. In HFpEF patients, but not in HFrEF patients, a lower mortality in relation to successful TTVR vs conservative therapy was observed after matching for age, EuroSCORE II, presence of a right ventricular lead and systolic pulmonary artery pressure. Based on these findings, it was concluded that TTVR, vs conservative therapy, might afford a treatment choice in patients suffering from severe TR and HFpEF.