Haddad A, et al. - In this systematic review and meta-analysis of 12 studies with 638 patients (mean age ranged from 68 to 84), researchers analyzed the use of transcatheter aortic valve replacement (TAVR) in patients with native aortic valve regurgitation (NAVR) and compared outcomes between first and second generation valves, taking into account all-cause mortality at 30 days. The systematic review included reports with at least 10 patients with aortic valve regurgitation undergoing TAVR procedure. Studies were identified from Medline, Embase, Cochrane, and Scopus databases from 2007 to 2018. For first-generation valves vs for second-generation valves, the incidence rate for all-cause mortality at 30 days was 15% vs 7%, respectively. Based on the findings, it appeared feasible to treat NAVR patients at high risk for surgical valve replacement with TAVR. In terms of short-term outcomes, promising results were displayed by second-generation valves.