Qiu HF, et al. - In this retrospective review, researchers compared transcatheter and intraoperative device closure and conventional surgical repair for treating atrial septal defect (ASD), focusing on the safety and efficiency of these treatments. Participants were patients (n=87) who had undergone transcatheter device closure (n = 45), intraoperative device closure (n = 22) and surgical repair (n = 20) for an isolated ASD between 2018 and April 2018. Findings revealed the safety as well as the effectiveness of all the abovementioned three treatments in patients with ASD. For an isolated secundum ASD, the first preference may be the transcatheter approach, and the second and the last resort may be the intraoperative approach and surgical repair, respectively, taking into account the respective disadvantages and benefits of these three approaches.