Wijnant SRA, De Roos E, Kavousi M, et al. - In the Rotterdam Study (population-based prospective cohort), researchers investigated the prevalence, trajectories and prognosis of Preserved Ratio Impaired Spirometry (PRISm) in the general population. Of the 5,487 individuals (age 69.1 ± 8.9; 7.1% PRISm), after 4.5 years, 1,603 have been re-examined. Data reported that mortality < 1 year was highest in PRISm, often having cardiovascular comorbidity (heart failure or coronary heart disease; 70.0%). Findings suggested an association of PRISm with increased mortality and this population includes at least three distinct subsets: one that develops COPD during follow-up, one with a high cardiovascular burden and early mortality, and one with persistent PRISm and normal age-related deterioration in lung function.