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Total antioxidant capacity and pancreatic cancer incidence and mortality in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

Cancer Epidemiology, Biomarkers & Prevention Feb 24, 2020

Zhong GC, Pu JY, Wu YL, et al. - In this study with the US general population, researchers investigated if higher total antioxidant capacity (TAC) is related to lower risks of pancreatic cancer incidence and mortality. From the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, overall 96,018 American adults were selected. This analysis involved 393 pancreatic cancer cases and 353 pancreatic cancer deaths. Experts estimated hazard ratios for pancreatic cancer incidence by employing Cox regression, and they calculated sub-distribution hazard ratios for pancreatic cancer mortality by applying competing risk regression. According to the findings, an inverse link of dietary but not supplemental TAC level with risks of pancreatic cancer incidence and mortality, in a non-linear dose-response pattern, was evident among the US general population.
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