Li S, et al. - Whether the presence of titin-truncating variants (TTNtv) could influence the phenotype of left ventricular noncompaction cardiomyopathy (LVNC) was investigated in a cohort of 83 adult patients with LVNC. Researchers used targeted sequencing to screen for TTN and also analyzed baseline and follow-up data. They primarily assessed a composite of death and heart transplantation; heart failure (HF) events, a composite of HF-related death, heart transplantation, and HF hospitalization was also evaluated after a median follow-up of 4.4 years was performed. A possible role by the presence of TTNtv as a genetic modifier of LVNC was suggested. Among adult TTNtv carriers, a higher risk of HF events was observed. Independent of sex, age, and baseline cardiac function, TTNtv were associated with an increased risk of heart failure events according to multivariable analyses.