Mulder V.C, et al. - Experts sought to measure the prothrombin fragments (F1+2) and thrombin-antithrombin complex (TAT) in vitreous and subretinal fluid (SRF) of rhegmatogenous retinal detachment (RRD) patients. They also aimed to validate and further specify the earlier finding of increased thrombin activity in patients with proliferative vitreoretinopathy (PVR). Significant thrombin generation was confirmed in both vitreous and SRF of patients with RRD with the analysis of F1+2 and TAT. The difference from the previous findings was possibly explained by the imbalance between the thrombin regulation mechanisms TAT and α2-macroglobulin.