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Thiol‐disulfide as a novel indicator of obstructive sleep apnea

The Clinical Respiratory Journal Mar 23, 2020

Argüder E, Parlak ES, Kılıç H, et al. - Researchers investigated a large patient population with obstructive sleep apnea (OSA) to assess thiol‐disulfide homeostasis in this patient group. Participants included 230 patients with OSA and 40 healthy controls. The patients who had apnoea‐hypopnoea index of ≥ 5/hour, were more than 18 years of age, and had received no previous treatment for OSA, were eligible for inclusion. Experts performed thiol‐disulfide analysis for the patients and control group. In this prospective analysis, OSA patients were found to have an unbalanced thiol/disulfide homeostasis. Especially, low level of thiol/disulfide redox parameters was observed among OSA patients vs healthy controls. It was suggested that assessing thiol‐disulfide homeostasis in OSA may be a contributing aspect to the evaluation as well as monitoring of the patient.

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