Bertaglia E, et al. - In an unselected real-world cardiac resynchronization therapy (CRT) population, researchers sought confirmation for the value of the VALID-CRT risk score as a predictor of outcome. They also focused on its link with clinical response (CR). Participants were all consecutive CRT patients (pts) included in the CRT MOdular Registry (CRT MORE) from 2011 to 2013. Based on the VALID-CRT risk predictor index employed to the CRT-MORE population, the participants were stratified into five groups (quintiles 1-5). Derived from the CRT-MORE population, the mean VALID-CRT risk score was 0.317, with a range from −0.419 in Q1 to 2.59 in Q5. The prediction of total mortality post-CRT and heart failure hospitalization was enabled by the risk-stratification algorithm. Pts with a high-to-very high risk profile (Q4-5) had significantly lower CR vs pts with a low-to-intermediate risk profile (Q1-2-3). Overall, the VALID-CRT risk-stratification algorithm was found to be reliable as a tool for predicting outcome and CRT response following CRT in an unselected, real-world population.