Sirico A, Lanzone A, Mappa I, et al. - Researchers investigated the strength of association of first-trimester fetal heart rate (FHR) in predicting the development of gestational diabetes (GDM). In this analysis, they included 603 singleton non-diabetic pregnant women who underwent a first-trimester screening at 11-14 weeks. Among these, 199 (33%) subsequently developed GDM. As per ROC analysis, high predictive value of first-trimester FHR for GDM was evident (AUC 0.809, 95% CI 0.769–0.849). For GDM, FHR showed a detection rate of 76.9%, the specificity of 67.1% and negative predictive value of 85.5% when threshold 162 bpm was considered. They identified this study as the first to illustrate the potential role of first-trimester FHR as early predictor of GDM.