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The relationship between myocardial fibrosis detected by cardiac magnetic resonance and tp-e interval, 5-year sudden cardiac death risk score in hypertrophic cardiomyopathy patients

Annals of Noninvasive Electrocardiology Jun 26, 2019

Demir AR, et al. - Researchers studied a total of 74 consecutive patients who underwent CMR with hypertrophic cardiomyopathy (HCM) diagnosis for the relationship between QT (QTc) interval, Tp-e interval, Tp-e/QTc ratio, 5-year sudden cardiac death (SCD) risk score, and late gadolinium enhancement (LGE) detected by CMR. Among 74 HCM patients, thirty-two (43.2%) had LGE as revealed by CMR and had significantly higher QTc interval, Tp-e interval, Tp-e/QTc ratio, and 5-year SCD risk score. Findings support the independent predictive value of Tp-e interval for LGE detected by CMR in HCM patients. Furthermore, the LGE could be detected using the Tp-e interval with a sensitivity of 64.3% and a specificity of 84.2% at 99.4 ms. These findings support the possible value of Tp-e interval in optimizing SCD risk stratification in HCM patients and ascertaining the patients who will benefit from implantable cardioverter-defibrillator (ICD) treatment.
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