Al-Diwani A, et al. - Given that most patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis present to psychiatrists and assuring its accurate clinical identification and prompt treatment is a necessity, researchers described the psychopathology of NMDAR-antibody encephalitis. Performing a systematic review, they identified 1,096 records in PubMed. Of these, inclusion criteria were filled by 333 records assessing 1,100 patients with NMDAR-antibody encephalitis. Of 464 individually-reported patients, the patients had a median age of 27 years, 368 (79%) were females and NMDAR-antibody encephalitis was related with ovarian teratoma in 147 (32%). The 464 patients were most frequently grouped into the following five higher-level categories: behavior (316 [68%]), psychosis (310 [67%]), mood (219 [47%]), catatonia (137 [30%]), and sleep disturbance (97 [21%]). As per constrained combination and principal component analyses, combinations of mood and psychosis syndromes were more suitable in describing each patient better vs any single diagnosis alone, especially for the those in the psychiatric-described subgroup. These findings suggest complexity is the distinguishing feature of NMDAR-antibody encephalitis psychopathology, as patients consistently show coexistence of core features of mood and psychotic disorders.