Tsuyuki K, et al. - Researchers analyzed data from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with viral load (VL) data (Brazil = 146; Thailand = 159), to assess whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. In Thailand, no significant association of substance use with VL undetectability or ART adherence was noted, however, an association was observed between alcohol misuse among MSM and increased odds of depression. In Brazil, an association was evident between alcohol misuse by MSM and decreased odds of undetectable VL. Among heterosexual men, polysubstance use was noted to be associated with decreased odds of ART adherence in Brazil. These findings suggest that non-injection substance users can attain VL suppression. Researchers recommend addressing depression, adherence, and VL undetectability while implementing substance use interventions among HIV-positive men.