Zhou F, et al. - Researchers studied 130 colon cancer patients to determine the differentially expressed lncRNAs between colon cancer tissue and adjacent tissue, and to gain insight into its biological functions. Colon cancer tissue showed significantly less expression of lncRNA XIRP2-AS1. In colon cancer tissues and cell lines, a remarkable downregulation of XIRP2-AS1 was seen. Functionally, the proliferation and invasion ability of colon cancer cells could be inhibited by XIRP2-AS1 in vitro and in vivo. In patients with colon cancer, the overall survival and progression free survival were favorably influenced by XIRP2-AS1, as revealed in clinical sample analysis. Overall, the possible role of XIRP2-AS1 as a favorable biomarker was suggested for patients with colon cancer in this study.