Al-Memar M, et al. - In this prospective observational cohort study conducted at Queen Charlotte’s & Chelsea Hospital, London, UK, researchers analyzed 847 pregnancies to determine how pelvic pain, vaginal bleeding and nausea and vomiting in the first trimester of pregnancy influence long-term pregnancy outcomes. In 166/645 (26%) women with pain and/or bleeding, and in 30/181 (17%) women without, adverse antenatal complications were reported. Neonatal complications were observed in 66/635 (10%) women with and 11/176 (6%) women without pain and/or bleeding. For 18 of 20 individual antenatal complications, women with pain and/or bleeding had higher incidence, despite the overall incidences being low. These findings suggest women with pelvic pain and/or vaginal bleeding in the first trimester to be at higher risk of antenatal complications. Women attending early pregnancy units should be advised considering these findings.