Lund K, et al. - In this nationwide cohort study involving 3,001 patients, researchers ascertained if anti-TNFα therapy changed the colectomy proportion and lessened the use of corticosteroids. The study sample consisted of patients, aged 0 to 20, diagnosed with ulcerative colitis through 1995-2015 from Danish health registries. After diagnosis, the cumulative 5-year risk of colectomy was calculated. For comparison between a historical pre-anti-TNFα cohort 1 (1995-2003) and a cohort 2 for the era of anti-TNFα (2004-2015), a Cox regression model was used. Data reported that the 5-year cumulative proportion of colectomy in cohort 2 was 9.7% and 12.3% in cohort 1. The adjusted 5-year hazard ratio (HR) was 0.76 for colectomy in cohort 2 vs cohort 1. The HR for colectomy within a period of 5 years from the time of diagnosis was decreased in the era of anti-TNFα compared with a historical cohort in patient's ≤ 20 years. Prescriptions of corticosteroids were virtually ceased after 12 months in patients treated with anti-TNFα