Tepeš B, Mlakar DN, Stefanovič M, et al. - In this study, changes in CRC incidence and mortality in Slovenia were examined after the first three rounds of the National Colorectal Cancer Screening Program (NCCSP). Two fecal immune tests (FITs) are employed in NCCSP, and patient is referred to colonoscopy if test is positive. From 2009, Slovenian residents aged 50–69 years are invited, one screening round takes 2 years. In 6.0–6.2%, FIT was positive (more in older patients and in men). For advanced neoplasia and cancer, odds ratio 2.19 was detected in patients with positive first FIT vs patients with two negative FITs. Findings revealed a significant decline in CRC incidence rate after 6 years in population as well as in men but not in women. A 31.3% higher 5-year CRC survival was observed if cancer was diagnosed in NCCSP. In patients with cancer identified outside the program, a 3.84 higher hazard ratio for death from CRC was estimated.