Stanaway JD, Parisi A, Sarkar K, et al. - Given a major causative role of non-typhoidal salmonella invasive disease for global morbidity and mortality, researchers investigated the burden of disease associated with non-typhoidal salmonella invasive disease for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017. Via performing a systematic review of scientific databases and grey literature, they identified the occurrence of 535,000 (95% uncertainty interval 409,000–705,000) cases of non-typhoidal salmonella invasive disease in 2017. The highest incidence was noted in sub-Saharan Africa and in children younger than 5 years. In 2017, there were reports of 77,500 (46,400–123,000) deaths; of which, 18,400 (12 000–27 700) were linked with HIV. Mean all-age case fatality was estimated to be higher among children younger than 5 years (13·5% [8·4–19·8]) and elderly people (51·2% [30·2–72·9] among those aged ≥ 70 years), people with HIV infection (41·8% [30·0–54·0]), and in areas of low sociodemographic development. These first global estimates of non-typhoidal salmonella invasive disease suggest the high disease burden, particularly in children, elderly people, and people with HIV infection. In view of these findings, they emphasize examining the sources and transmission pathways of non-typhoidal salmonella invasive disease to implement effective preventive and control measures.